I had this same problem (error:The Sims 4 Studio - Version 18.104.22.168
System.AggregateException: One or more errors occurred. ---> SQLite.SQLiteException: Could not open database file: ...) , and after hours of searching for a solution I tried the last thing I could possibly think of ... I disabled my antivirus software (avast), then I reinstalled and launched sims 4 studio... and it worked. After I made sure everything works okay, I enabled avast and everything still looks okay.
So... i'm not saying this is a solution, ... it worked for me... I don't know if it will for you too. p.s. sorry for my bad english... I tried my best. :D
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